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- W2372487961 abstract "Purpose:To investigate the expression of TGF-β1,Cyclin E in (primary) gallbladder carcinoma and its clinical significance. Methods:The expression of TGF-β1,Cyclin E in gallbladder carcinoma was detected by S-P immunohistochemical staining,20 cases of chronic cholecystitis were collected as control. Results:①The positive rate of TGF-β1(63.89%),Cyclin E(47.22%) in gallbladder carcinoma increased significantly(P0.05).②The positive rate of TGF-β1 was higher in metastasis or Nevin Ⅳ-Ⅴ stage group of gallbladder carcinoma than in non-metastasis or Nevin Ⅰ-Ⅲ stage group(P0.05).In metastasis or low differentiation there was also higher expression of Cyclin E(P0.05). ③The expression of Cyclin E was inversely correlated with the expression of TGF-β1(P0.05). ④There was significant difference in survival time between patients with TGF-β1+ and TGF-β1-. The difference was also shown between patients with Cyclin E + and Cyclin E-. There were statistically signiticant correlations between the first group and the second group. Conclusions:①The up regulation of TGF-β1,Cyclin E in gallbladder carcinoma indicates the imbalance of TGF-β1/ Cyclin E system and might play a role in tumor pathology and prediction of the malignant behavior of the carcinoma.②The detection of TGF-β1,Cyclin E may be useful in assessing the development of the cancer,judging prognosis and eventually render a possible target for novel therapeutic strategies." @default.
- W2372487961 created "2016-06-24" @default.
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- W2372487961 date "2004-01-01" @default.
- W2372487961 modified "2023-09-27" @default.
- W2372487961 title "Expression and clinical significance of tGF-β1,Cyclin E in gallbladder carcinoma" @default.
- W2372487961 hasPublicationYear "2004" @default.
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