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- W2372495219 abstract "Objective To observe the effect of Yinao capsule on the learning,memory and pathological changes in rat model with Alzheimer's disease(AD) induced by aluminum chloride via intrathecal injection,and to explore its action mechanism. Methods Adult SD rats were divided into three groups,model group,experimental group and control group. The rats in model group were administrated with aluminum chloride by intrathecal injection for 5 days on the last 28 days after injection,whether the model was successful was evaluated by dark avoidance test and pathological changes. The rats with AD were treated with Yinao capsule for 6 months,then the rats were killed to observe the changes of morphous and distribution of neurons in hippocampal CA1 area and parietal cortex,and to observe the changes of expression of β-AP,β-APD and tau protein by using immune hybridization and in situ hybridization technique. Results The times of error in AD model group increased,and incubation period was shorted,the expression of β-AP,β-APP,tau protein significantly increased,as compared with that in control group (P0.05). However there were no significant differences in these parameters between treatment group and control group(P0.05). Conclusion The anti-oxidation effect induced by Panaxoside and Schisandra in Yinao capsule may be one of the mechanisms to improve learning,memory and pathological changes in AD rats." @default.
- W2372495219 created "2016-06-24" @default.
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- W2372495219 date "2009-01-01" @default.
- W2372495219 modified "2023-09-23" @default.
- W2372495219 title "The observation on the pathological changes caused by Yinao capsule in the treatment of Alzheimer's disease in rats" @default.
- W2372495219 hasPublicationYear "2009" @default.
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