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- W2372510108 abstract "OBJECTIVE: To develop a bioinformatics-based approach for analysis of cellular functions and pathways affected by differently expressed microRNAs in different ER status of breast cancers and explore the regulatory roles of microRNAs.METHODS: By literature metrological methods,aberrant expressed microRNAs were collected.By target prediction algorithm TargetScan,PicTar and miRanda,TarBase database and data enrichment analysis as well as target gene sets of differently expressed microRNAs were built.Then by using of DAVID database,Gene Ontology categories and biological functions as well as signaling pathways that are probably regulated by differently expressed microRNAs were analysed.RESULTS:Five sets of microRNAs including 11,43,25,6 and 19 respectively were found.After microRNAs target prediction and a two-step data enrichment procedure,1 553,1 750,1 905,1 250 and 1 826 target genes of 5 microRNA sets were collected.Gene Ontology analysis suggested these genes might involve in transcription,protein location and transport,RNA metabolism,cell cycle and apoptosis.Also,3 BIOCARTA signal pathways correlating with ER status were found.CONCLUSION: This bioinformatics-based approach for analysis of differently microRNAs in different ER status breast cancers provides a new method for biological interpretation of microRNAs profiling data,and may be helpful to understand the regulatory roles of microRNAs in different molecular subtypes of breast cancers." @default.
- W2372510108 created "2016-06-24" @default.
- W2372510108 creator A5040705931 @default.
- W2372510108 date "2012-01-01" @default.
- W2372510108 modified "2023-09-26" @default.
- W2372510108 title "Bioinformatics-based analysis of signaling pathways for differently expressed microRNAs between different ER status breast cancers" @default.
- W2372510108 hasPublicationYear "2012" @default.
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