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• W2372510539 endingPage "1046" @default.
• W2372510539 startingPage "1035" @default.
• W2372510539 abstract "Therapeutic drug monitoring (TDM) relays in the availability of specialized laboratory assays, usually available in reference centers that are not accessible to all patients. In this context, there is a growing interest in the use of dried blood spot (DBS) sampling, usually obtained from finger pricks, which allows simple and cost-effective logistics in many settings, particularly in Developing Countries. The use of DBS assays to estimate plasma concentrations is highly dependent on the hematocrit of the blood, as well as the particular characteristics of the measured analyte. DBS assays require specific validation assays, most of them are related to hematocrit effects. In the present manuscript, the application of mass spectrometric assays for determination of drugs for TDM purposes in the last ten years is reviewed, as well as the particular validation assays for new DBS methods." @default.
• W2372510539 created "2016-06-24" @default.
• W2372510539 creator A5048102258 @default.
• W2372510539 creator A5058840924 @default.
• W2372510539 creator A5074110261 @default.
• W2372510539 date "2016-09-01" @default.
• W2372510539 modified "2023-10-18" @default.
• W2372510539 title "Dried blood spots analysis with mass spectrometry: Potentials and pitfalls in therapeutic drug monitoring" @default.
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• W2372510539 doi "https://doi.org/10.1016/j.clinbiochem.2016.05.004" @default.
• W2372510539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27179588" @default.
• W2372510539 hasPublicationYear "2016" @default.
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