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- W2372518132 abstract "We aimed to investigate whether partial injury of the dorsal root can induce neuropathic pain in the rat and sympathetic activities contribute to the neuropathic pain behavior After a partial ligation of lest L 5 dorsal root behavioral measures and electrophysiological study were performed All rats with partial dorsal root injury developed mechanical hypersensitivily as early as the first postoperative day and lasted for 30 days Sympathectomy done prior to 12 days of the partial injury of the dorsal root inhibited the development of the mechanical hypersensitivity Sys- temic application of phentolamine (4kg/kg.i.p.)an alpha adrenoreceptor antagonist significantly decreased the mechanical sensitivity and lasted for 30 minutes Spontaneous activity was found in 162 of 746 (21.7%)A-fibers recorded from the injured rootlets and 38/39 injured A-fibers with spontaneous activity responded to NE systemically administrated (1 m g)or topically to the DRG (0.5mmol)64.1%of recorded fibers (25/39)were excited and the other 33.3%(13/39)were inhibited The results suggests that sympathetic activities contribute to the mechanical allodynia induced by partial injury of the dorsal root" @default.
- W2372518132 created "2016-06-24" @default.
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- W2372518132 date "2000-01-01" @default.
- W2372518132 modified "2023-09-26" @default.
- W2372518132 title "Sympathetic contribution to mechanical allodynia induced by partial injury of the dorsal root in the rats" @default.
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