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- W2372526782 abstract "Objective To investigate changes of PGE2 in peripheral blood and sputum from patients with chronic obstructive pulmonary disease,and to investigate its clinical significance.Methods The serum and sputum levels of PGE2 were determined both in acute exacerbation and in remission stages in 30 cases of COPD and we analyzed its correlation with FEVl% pre.Results The serum and sputum levels of PGE2 in the acute exacerbation and remission stages of COPD groups were both higher than those in the normal control group.The levels of PGE2 in the acute exacerbation stage were higher than those in the remission stage(P0.05).In the COPD group,the serum and sputum levels of PGE2 negatively correlated with FEV1% pre(r=-0.45,P0.05) in the acute exacerbation and remission stages.Conclusions There are different serum and sputum levels in different periods of COPD,and there are certain relationships between these indexes and pulmonary function.These findings suggest that PGE2 participates in the development of COPD and plays an important role in the airway inflammation and airway obstruction of COPD." @default.
- W2372526782 created "2016-06-24" @default.
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- W2372526782 date "2012-01-01" @default.
- W2372526782 modified "2023-09-28" @default.
- W2372526782 title "The detection and significance of PGE2 in peripheral blood and sputum from patients with chronic obstructive pulmonary disease" @default.
- W2372526782 hasPublicationYear "2012" @default.
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