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- W2372529844 abstract "Objective:A nutritional iron deficient model of pregnancy rats was established to explore the effect of low-iron intervene in pregnant rat on cytokine of its offspring.Method:Six week-age Wistar female rats were divided into two groups randomly :experimental group were feeded with low-iron diet,control group were feeded with iron-sufficient diet.They were mated with healthy male rats after four weeks and the iron intervention were carried out untill the lactation period ended.Iron-sufficient diet were then given to all rats for seven weeks and we called this iron balancing period.After that control group and experimental group were divided into two groups respectively and all the rats were killed to detect the serum level of TNF-α,IL-6,and EPO after forteen weeks.Results:Compared with control group,weight and the level of serum TNFα,EPOand IL-6 of the offspring whose mother feeded with low-level iron diet in pregnancy were elevated significantly after lactation and balancing period.It appears the phenomenon of catching up.Conclusion :Weight of the offspring whose mother were given low iron intervention in pregnancy grew rapidly to exceed their control group.after lactation and being given iron-sufficient diet.So we speculated that iron deficiency willleading to the level of cytokine,The situation became worse when low iron intervention were carried out in early life.and that may result in the cytokine-induced immune response." @default.
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- W2372529844 date "2009-01-01" @default.
- W2372529844 modified "2023-09-25" @default.
- W2372529844 title "Effect of low-iron intervention in pregnant rat on cytokine of its offspring" @default.
- W2372529844 hasPublicationYear "2009" @default.
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