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- W2372537851 abstract "Objective To explore the relationship between insulin resistance(IR) and severity of coronary heart disease(CHD) and in-hospital prognoses of patients.Methods Totally 355 patients confirmed by coronary angiography were enrolled in the present study.They were divided into four groups according to the number of vessels involved: one-vessel group,two-vessel group,multi-vessel group and normal control group.Homeostasis model assessment of insulin resistance index(HOMA-IR) and Gensini's score of coronary stenosis were calculated.We analyzed the influence of IR on severity of coronary artery stenosis and heart function.Results Gensini's score was significantly increased with the number of vessels involved,while left ventricular ejection fraction(LVEF) was significantly different decreased with the number of vessels involved(P0.01).And the LVEF values were also significantly between one-vessel group,two vessel group and multi-vessel group(P0.05,0.01).We also found that the HOMA-IR values were positively correlated with the body mass index(BMI,r=0.114,P=0.032),triglycercide(TG,r=0.223,P0.01),total cholesterol(TC,r=0.152,P=0.004),low density lipoprotein cholesterol(LDL-C,r=0.244,P0.01),fasting plasma glucose(FPG,r=0.473,P0.01),fasting insulin(FINS,r=0.920,P0.01),Gensini's score(r=0.401,P0.01),left ventricular end-diastolic diameter(LVEDD,r=0.162,P=0.002),and left ventricular end-systolic diameter(LVESD,r=0.140,P=0.008);and were negatively correlated with LVEF(r=-0.145,P=0.006).After adjusting age,blood pressure,blood glucose,and blood lipids,HOMA-IR values were still positively correlated with Gensini's score(r=0.349,P0.01).Multivariate linear regression model showed that FPG,Gensini's score,LVEDD and TG were independent factors of HOMA-IR,while FINS,TC,LVEF and LVESD were independent factors of Gensini's score.The CHD patients were divided into the following 2 groups: 66 patients with higher HOMA-IR(group IR,HOMA-IR≥5) and 183 patients with lower HOMA-IR(group NIR,HOMA-IR5).The incidence of heart failure(12.12%) and mortality(10.61%) in group IR were significantly higher than those in group NIR(2.73%,2.73%,P0.01,0.05).Conclusions Insulin resistance in patients with CHD is closely correlated with the severity of coronary artery stenosis and a high risk of in-hospital heart failure and death.(Shanghai Med J,2011,34: 351-355)" @default.
- W2372537851 created "2016-06-24" @default.
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- W2372537851 date "2011-01-01" @default.
- W2372537851 modified "2023-09-23" @default.
- W2372537851 title "Study on relationship between insulin resistance and severity of coronary heart disease" @default.
- W2372537851 hasPublicationYear "2011" @default.
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