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- W2372544944 abstract "Objective To investigate the protective effect of ischemic preconditioning( IPC) on skeletal muscle injury after limbs ischemia- reperfusion,and to investigate the role of nitrogen monoxide( NO) in this process. Methods Thirty- two male Wistar rats were randomly divided into four groups( n = 8) : sham group( sham operation alone,Group S),limbs ischemia- reperfusion group( subjected to 4 h of hindlimb ischemia and 4 h reperfusion,Group M),preconditioning group( four cycles of 5 minutes occlusion and reperfusion of both hindlimbs before ischemia- reperfusion,Group P) and Nω- nitro- L- arginine methylester treated group( pretreated with L- NAME 10 mg / kg 15 minutes before ischemia- reperfusion,Group T). The plasma NO,endothelin- 1( ET- 1) and NO / ET- 1 in plasma,and the NO,ET- 1,NO / ET- 1,malondialehyde( MDA),myeloperoxide( MPO) and the ratio of DNA double chain in gastrocnemius tissue were measured. The immunohistochemistry( IHC) method was used to assessthe expressions of Bcl- 2,Bax and Caspase- 3,while TUNEL was applied for apoptosis analysis. Results Significant elevation in NO and ET- 1 wasobserved in both plasma and gastrocnemius tissue in Group M whencompared with those in Group S,with significant reduction in NO / ET- 1. Meanwhile,significant increase of MDA,MPO,Caspase- 3 and apoptosis index( AI) and reduction in the ratio of DNA double chain and Bcl- 2 / baxin gastrocnemius tissues in Group M. Significant elevation of NO and the NO / ET- 1 and reduction in ET- 2 were observed in both plasma and gastrocnemius tissues in Group P when compared with those in Group M. Meanwhile,significant reduction in MDA,MPO,Caspase- 2 and AI,and increase in the ratio of DNA double chain and Bcl- 2 / Bax in gastrocnemius tissues were also observed in Group P than Group M( P 0. 01).Significant reduction in NO and NO / ET- 1 in both plasma and gastrocnemius tissues was observed in Group T than those in Group P. Furthermore,significant increase of MDA,MPO,Caspase- 3 and AI,and reduction in the ratio of DNA double chain and Bcl- 2 / Bax in gastrocnemius tissues were revealed in Group T than those in Group P( P 0. 01). Conclusion PC can preventthe gastrocnemius injury from hindlimbs ischemia- reperfusion,which maybe correlated withincrease of NO." @default.
- W2372544944 created "2016-06-24" @default.
- W2372544944 creator A5089611409 @default.
- W2372544944 date "2013-01-01" @default.
- W2372544944 modified "2023-09-23" @default.
- W2372544944 title "The protective effect of preconditioning on skeletal muscle withlimb ischemia- reperfusion" @default.
- W2372544944 hasPublicationYear "2013" @default.
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