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- W2372556907 abstract "Objective Explore the apoptosis mechanism of small molecule S1 on B16 cells and improve the therapeutic effect of S1.Methods B16 cells were divided into four groups,control group,S1 2.5 μM group,S1 5 μM group and S1 10 μM group respectively.The survival rate of B16 cells was determined by MTT.The apoptosis rate of B16 cells was determined by Flow cytometry analysis.The apoptosis relative proteins were determined by Western blotting.Results Compared with control group,S1 can decrease the survival rate of B16 cells(P0.05).Small molecule S1 can increase the apoptosis rate of B16 cells significantly.The results of Western Blotting showed that the apoptosis-relative protein cleaved caspase-3 and mitochondrial apoptosis-relative protein Cytochrome C were increased significantly(P0.05).Conclusion Small molecule S1 maybe induce B16 cells apoptosis through mitochondrial apoptosis pathways." @default.
- W2372556907 created "2016-06-24" @default.
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- W2372556907 date "2012-01-01" @default.
- W2372556907 modified "2023-09-30" @default.
- W2372556907 title "The research of mechanism that micromolecule compound S1 induce B16 cell apoptosis" @default.
- W2372556907 hasPublicationYear "2012" @default.
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