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- W2372569572 abstract "Objective To observe the expressions of aquaporin 1(AQP1) and aquaporin 5(AQP5) in submaxillary salivary gland of rats with Sjogren's syndrome(SS),and observe their changes by Xinfeng Capsules(XFC),a traditional Chinese prescription for rheumatoid arthritis.Methods Fifty SD rats were averagely randomized into normal control group,model group and hydroxychloroquine(HCQ) treated group,total glucosides of peony(TGP) treated group,and XFC treated group.All rats except those in the normal control group were injected with 0.2 ml mixed antigen containing fully emulsificated proteins of submaxillary salivary gland and Freund's complete adjuvant,in order to induce SS rat model.Pathological changes of rat submaxillary salivary gland were observed by conventional light microscope.AQP1 and AOP5 expressions of submaxillary salivary gland in each group were detected by immunohistochemical assay,and the changes of body masses were also observed.Results(1)Compared with those in normal control group,body masses and the expressions of AQP1 and AQP5 were significantly decreased in SS rats in the model group(P0.05).(2)Compared with those in the model group,the above mentioned indicators were significantly increased in HCQ-,TGP-and XFC-treated groups(P0.05);(3)Compared with those in HCQ-and TGP-treated groups,body masses were significantly increased in SS rats in XFC treated group(P0.05),while the changes of AQP1 and AQP5 were not statistically significant(P0.05).Conclusion XFC can regulate the cellular immune environment and increase the body masses of SS rats,via up regulating the expressions of AQP1 and AQP5." @default.
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- W2372569572 date "2012-01-01" @default.
- W2372569572 modified "2023-09-23" @default.
- W2372569572 title "Effects of Xinfeng Capsules on Aquaporin-1 and-5 in Rats with Sjogren's Syndrome" @default.
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