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- W2372575574 abstract "OBJECTIVE To study the synthesis and anti-inflammatory activities of 3-esterified derivatives of glycyrrhetinic acid.METHODS On the basis of construction related medical effect of glycyrrhetinic acid,five new 3-esterified derivatives of glycyrrhetinic acid were synthesised with glycyrrhetinic acid,amino acid and imidazole heterocyclic compounds.Their structures were all confirmed by IR,1HNMR and MS,and their anti-inflammatory activities were also evaluated with the model xylene-induced ear edema in mice.RESULTS The 5 target compounds had the inhibitory effect on xylene-induced ear edema in mice,and some compounds had higher inhibition rates than Hydrocortisone.CONCLUSION All of the 5 target compounds have anti-inflammatory activities,and the anti-inflammatory activities are comparable to Hydrocortisone,and some have higher anti-inflammatory activities than Hydrocortisone." @default.
- W2372575574 created "2016-06-24" @default.
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- W2372575574 date "2009-01-01" @default.
- W2372575574 modified "2023-09-27" @default.
- W2372575574 title "Synthesis and anti-inflammatory activity of 3-esterified derivatives of glycyrrhetinic acid" @default.
- W2372575574 hasPublicationYear "2009" @default.
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