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- W2372575576 abstract "Background: The purpose of this study was to evaluate the relationship between chemokines and dendritic cells (DCs) in human chronic periodontitis (CP). Methods: Gingival samples were obtained from 23 individuals with CP, and six samples of normal mucosa (NM) overlapping the third molar were used to control for the chemokine levels. Periodontal examination was conducted. Immunohistochemistry was performed for Factor XIIIa + and cluster of differentiation (CD)1a + immature DCs and CD83 + mature DCs. Levels of the CC chemokine ligand (CCL)2, CCL3, CCL5, CCL19, CCL20, and CXC chemokine ligand (CXCL)8 were measured in gingival tissues using enzymelinked immunosorbent assay. Inflammatory infiltrate, DCs, chemokines, classification of human CP, and clinical parameters were correlated and compared. Results: The expression of CCL2 and CCL20 was positively correlated with increased densities of CD1a + DCs. CCL3 and CXCL8 were positively related to the clinical attachment level. CCL3, CCL5, CCL19, and CXCL8 levels increased in the gingival samples of patients with CP compared with NM, whereas CCL20 levels increased in advanced CP compared with mild‐moderate CP. Conclusions: More CD1a + immature DCs are related to CCL2 and CCL20. CCL3 and CXCL8 chemokines are related to a greater severity of human CP. J Periodontol 2014;85: 1416-1423." @default.
- W2372575576 created "2016-06-24" @default.
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- W2372575576 date "2014-01-01" @default.
- W2372575576 modified "2023-09-24" @default.
- W2372575576 title "Relationship Between Chemokines and Dendritic Cells in Human Chronic" @default.
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