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- W2372585557 abstract "Objective:To explore the effect of atorvastatin on resistance index of carotid artery after adventitia removal in spontaneously hypertensive rats(SHR).Method:Sixteen-week old male SHR(n=36)with removed left carotid artery adventitia were randomly divided into three groups(n=12,each):SHR control group,atorvastatin group and valsartan group,and half of each group were put to death at 4th and 8th week respectively.The systolic blood pressure was assessed before and after treatment with atorvastatin every 2 week.The velocity of carotid artery was detected by electromagnetic rheometer.Result:There was no difference of SBP among three groups before operation and treatment(P0.05).Compared with that in SHR group,systolic blood pressure in atorvastatin group began to decrease at the 4th week,and significantly reduced at the 6th and 8th week([166.17±7.20] mmHg vs [183.50±8.46]mmHg and [159.00±11.21] mmHg,P0.05 and P0.01).The resistance index of carotid artery was reduced more significantly in atorvstatin group and valsartan group than that in SHR group([4.937±0.359] vs [5.3266±0.371],[3.6725±0.161] vs [5.3266±0.371],P0.05 and P0.01).Conclusion:Atorvastatin may lower the vascular resistance in SHR,including the side without adventitia removal." @default.
- W2372585557 created "2016-06-24" @default.
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- W2372585557 date "2006-01-01" @default.
- W2372585557 modified "2023-09-25" @default.
- W2372585557 title "Effect of atorvastatin on resistance index of carotid artery after adventitia removal in spontaneously hypertensive rats" @default.
- W2372585557 hasPublicationYear "2006" @default.
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