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- W2372591149 abstract "Objective:To compare the therapeutic effects of Xianling Gubao(XLGB) extracts by microwave-assisted extraction(MAE) and traditional extraction(TE) on osteoporosis,and to provide data for the further generalization of MAE and clinical application of XLGB.Method: Healthy SD rats were randomly divided into 7 groups: normal control group,osteoporosis model group,Fosamax group,middle-dose of XLGB by TE group(1.0 g·kg-1),low-dose of XLGB by MAE group(0.33 g·kg-1),middle-dose of XLGB by MAE group(1.0 g·kg-1),high-dose of XLGB by MAE group(3.0 g·kg-1).In the morning all the rats except the normal control group were given retinoic acid(80 mg·kg-1)through intragastric administration for 2 weeks,at the same time in the afternoon all the rats except the normal control group and the osteoporosis model group were given corresponding drugs once per day for 4 weeks.After that,bone density(BMD) of tibial metaphysis,femoral metaphysis and lumbar were determined.Result: Compared with the normal control group,the BMD of tibial metaphysic(0.267 5±0.011 9) g·cm-2,femoral metaphysic(0.228 9±0.015 2) g·cm-2 and lumbar(0.247 1±0.012 6) g ·cm-2 of the osteoporosis model group were obviously decreased(P0.01);compared with the osteoporosis model group,the BMD of tibial metaphysis,femoral metaphysis and lumbar of all the administration group were obviously increased(P0.05 or P0.01);compared with middle-dose of XLGB by TE group(0.272 7±0.013 3)g·cm-2,the BMD of tibial metaphysis of middle-dose of XLGB by MAE group(0.283 3±0.020 0)g·cm-2 were obviously increased(P0.05);only did the BMD of tibial metaphysic(0.290 1±0.014 3)g ·cm-2,femoral metaphysic(0.251 5±0.006 7)g·cm-2and lumbar(0.261 7±0.007 9)g·cm-2 of the high-dose of XLGB by MAE group have no obvious differences with Fosamax group.Conclusion: The therapeutic effect of XLGB by MAE on osteoporosis was exact and dose dependent.The effect of XLGB by MAE was better than that by TE.It is suggested that more attention should be paid to the therapeutic effect and safety of MAE." @default.
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- W2372591149 date "2012-01-01" @default.
- W2372591149 modified "2023-09-25" @default.
- W2372591149 title "Therapeutic Effects of Microwave-assisted Extract of Xianling Gubao on Experimental Osteoporosis in Rats" @default.
- W2372591149 hasPublicationYear "2012" @default.
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