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- W2372593782 abstract "Objective To investigate the expression of matrix metalloproteinase-2(MMP-2),vascular endothelial growth factor(VEGF),CD105 and Ki-67,the correlations among the 4 indicators,the clinical features and prognosis in small cell lung cancer(SCLC).Methods From 2004 to 2009,42 cases of SCLC and 8 cases of normal lung tissues were collected.The expression of MMP-2,VEGF,CD105 and Ki-67 were detected by immunohistochemistry SP method.The correlation among expression of MMP-2,VEGF,CD105 and Ki-67,clinical features and prognosis were analyzed.Results The positive rate of MMP-2,VEGF,CD105 and Ki-67 was 50.0%,66.7%,81.0% and 64.3% in 42 cases of SCLC tissues,higher than 12.5%,12.5%,0 and 0 in normal lung tissues(P0.05).The expression of MMP-2,VEGF and CD105 was correlated with tumor size,lymph node metastasis,distant metastasis and clinical stage(P0.05),while Ki-67 was only correlated with lymph node metastasis(P0.05).The expression of MMP-2 and VEGF was correlated with CD105 and Ki-67,and there were significant positive correlations between MMP-2 and VEGF(r=0.447,P0.05).Single factor survival analysis showed that tumor size,lymph node metastasis,distant metastasis,clinical stage,and MMP-2,VEGF,CD105 and Ki-67 expression was correlated with the overall survival of SCLC.Conclusion MMP-2,VEGF,CD105 and Ki-67 are prognostic predictors in SCLC.The correlation of MMP-2 and VEGF may participate in angiogenesis and proliferation of SCLC." @default.
- W2372593782 created "2016-06-24" @default.
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- W2372593782 date "2012-01-01" @default.
- W2372593782 modified "2023-09-24" @default.
- W2372593782 title "Correlation between the expression of MMP-2,VEGF,CD105 and Ki-67 in small cell lung cancer and their prognostic value" @default.
- W2372593782 hasPublicationYear "2012" @default.
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