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- W2372597092 abstract "Objective To investigate whether the different expression of PRDM1,a cell differentiation-related gene,in lymphoma cells is affected by histone methylation.Methods CHIP technique was used to detect the histone methylation status in B-lymphoma cell lines Namalwa and SU-DHL-4,as well as the T-lymphoma cell line H9 and human embryonic kidney 293T.Results Cells having different expression level of PRDMI had different levels of H3K4m3 and H3K9m3,high level H3K4m3 was associated with high expression of PRDM1,while high level H3K9m3 was associated with down-regulation of PRDMI expression.Conclusions Expression of PRDM1 gene was correlated with histone methylation,and the later might be a possible mechanism of PRDM1 gene transcription modulation." @default.
- W2372597092 created "2016-06-24" @default.
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- W2372597092 date "2011-01-01" @default.
- W2372597092 modified "2023-09-22" @default.
- W2372597092 title "The effect of histone methylation on PRDM1 gene expression in malignant lymphoma" @default.
- W2372597092 hasPublicationYear "2011" @default.
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