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- W2372600392 abstract "Objective: To observe the influence of Tong Xie Yao Fang on the PPAR-γ mRNA and protein expressions of colonic mucosa in rats with experimental ulcerative colitis(UC),and identify its underlying mechanism of action.Methods: Dividing the experimental animals into 6 groups,we prepared the models by means of the TNBS/ethanol enema,observed their morphological injury and damaged with the naked eye,and detected PPAR-γ gene and protein expressions by means of RTPCR and immunohistochemical with PPAR-γ being the observation targets.Results: Inflammation and ulceration were with the naked eye observed on the colonic mucous membrane of rats in the model group,and compared with the blank group,and the models were proved successful(P0.05).The relative expression amount of PPAR-γ gene and protein of colonic tissues of rats in the model group were decreased than that of the blank group,and the discrepancy was statistically significant(P0.01);after the treatment,compared with the model group,the relative expression amount of PPAR-γ gene and protein in the Tong Xie Yao Fang high-and moderate-dose groups were increased,and the discrepancy was statistically significant(P0.05,P0.01).Conclusion: The Tong Xie Yao Fang can promote the relative expression amount of PPAR-γ gene and protein of colonic tissues of rats with UC,which suggests the therapeutic effects of the Tong Xie Yao Fang is probably related to the activation of PPAR-γ/NF-κB signal transduction pathway." @default.
- W2372600392 created "2016-06-24" @default.
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- W2372600392 date "2013-01-01" @default.
- W2372600392 modified "2023-09-25" @default.
- W2372600392 title "Influence of Tong Xie Yao Fang on the PPAR-γ mRNA and protein expressions of colonic mucosa in rats with experimental ulcerative colitis" @default.
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