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- W2372608540 abstract "Objective:To investigate the diagnostic Value of serum levels of CA242,CA19-9 and CA125 to Pancreatic cancer.Methods:Total plasma levels of CA242 were measured by IRMA methods,and CA19-9 and CA125 were measured by CLIA methods in blood samples from 36 healthy donors and 116 patients with PC,benign pancreatic lesions,benign hepatobiliary diseases and other malignancies,and their diagnostic value were assessed.Results:The patients with PC had significantly elevated CA242 and CA19-9 serum levels.CA125 serum levels were elevated in patients with pc or in patients with benign pancneatic lesions and with other malignant diseases. The serum levels of CA242,CA19-9and CA125 in non-resectable patients with PCwere significantly higher than that in patients with resectable PC(P0.05).With these commended cutoffs(22u/ml for CA242,37u/ml for CA19-9and 35u/ml for CA125),we obtained a sensitivity of 76.19% for CA242,85.71%for CA19-9and 66.67%for CA125;The specificity was 87.84%、72.97% and 74.74% for CA242,CA19-9 and CA125,respectively. Combining CA242and CA19-9 measurements increased the sensitivity and specificity obtained from CA242 or CA19-9 alone.Conclusions:CA242 and CA19,because of their high sensitivity and specificity,may be considered as markers for the assessment of resectablity of tumour and prognosis of PC. CA242 has a higher specificity than CA19-9. Combiming CA242and CA19-9 measurements is a excellent combined fashion and can greatly enhance the diagnosis of patients with PC." @default.
- W2372608540 created "2016-06-24" @default.
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- W2372608540 date "2005-01-01" @default.
- W2372608540 modified "2023-09-23" @default.
- W2372608540 title "Diagnostic value of serum levels of CA242,CA19-9 and CA125 to patients with pancreatic cancer" @default.
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