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- W2372609229 abstract "Objective:To investigate the expression of Notch4 gene and protein in the hematopoietic system in mouse early embryos.Methods:The expression of Notch4 mRNA and protein of the Hematopoietic system form the mouse embryonic aorta-gonad-mesonephros(AGM)region and fetal liver at embryonic day(E)9.5,E10.5,E11.5,E12.5 were detected by RT-PCR and Western blot techniques.Results:In two groups of mouse early relevant hematopoietic tissue,Notch4 mRNA and protein expression of E10.5 group were significantly higher than other groups(P0.05)in the AGM area,and decreased with the pregnancy in both the AGM and fetal liver(P0.01).There was statistical difference at embryonic day(E)9.5 and 12.5 in the area comparison between AGM and fetal live(P0.05).There was no statistical significance(P 0.05)at embryonic day(E)10.5 and 11.5.PT-PCR showed the same expression rules.Conclusion:The Notch4 signals are expressed in early hematopoietic tissue of mouse embryos,but its function is to be further researched." @default.
- W2372609229 created "2016-06-24" @default.
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- W2372609229 date "2011-01-01" @default.
- W2372609229 modified "2023-09-24" @default.
- W2372609229 title "Expression of Notch4 in hematopoietic system during early mouse development" @default.
- W2372609229 hasPublicationYear "2011" @default.
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