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- W2372617185 abstract "AIM and METHOD:The change of lung function induced by oxygen free radicals and effect of exogenous surfactant replacement on oxygenation of injuried rat lungs were studied.RESULTS:P aO 2 and lung-thorax compliance measured after intratracheal instillation of xanthine and xanthine oxidase were significantly reduced.In morphological study,the increase of lung weight to body weight ratio was demonstrated,and there were perivascular edema and infiltration with neutrophils microscopically.The analysis of bronchoalveolar lavage fluid showed a reduction of surfactant and an increase of protein content.After surfactant administration to injured rats,the lung oxygenation was highly improved with an increase of P aO 2 from a means of 32.4 kPa to 47.5 kPa( P 0 01).CONCLUSION:The changes of pulmonary surfactant content differ in the stage of lung injury and that exogenous surfactant replacement therapy might be a rational approach to the treatment of acute respiratory failure caused by various factors." @default.
- W2372617185 created "2016-06-24" @default.
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- W2372617185 date "1999-01-01" @default.
- W2372617185 modified "2023-09-23" @default.
- W2372617185 title "The improvement of oxygenation of injuried lungs by exogenous surfactant replacement in rats" @default.
- W2372617185 hasPublicationYear "1999" @default.
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