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- W2372631398 abstract "Objective In order to explore the effects of trauma on MAC and its mechanism, the changes in MAC of sevoflurane and plasma β endorphin were investigated in state of trauma. Methods Twenty New Zealand rabbits were randomly divided into control group and trauma group. MAP,CVP, P ET CO 2 and ECG were monitored continuously. The MAC of sevoflurane was measured in the two groups. In trauma group, the left femur of rabbits was fractured combined with parenchyma damage.Plasma β endorphin concentration was assaied at various times in two groups. Results MAC of sevoflurane was 2 2%±0 2% in control group and 1 7%±0 2% in trauma group. Trauma induced increase of plasma β endorphin concentration significantly 5min and 30min after trauma,β endorphin concentration increased by 44% and 52% in trauma group, respectively. Conclusions MAC of sevoflurane in rabbits is 2 2%±0 2%.Trauma can reduce MAC of inhalational anesthetic significantly. The endogenous β endorphin releasing enormously induced with trauma may be one of the mechanisms to decrease MAC of inhalational anesthetics." @default.
- W2372631398 created "2016-06-24" @default.
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- W2372631398 date "2000-01-01" @default.
- W2372631398 modified "2023-09-23" @default.
- W2372631398 title "Influence of trauma on MAC of sevoflurane and plasma β-endorphin concentration" @default.
- W2372631398 hasPublicationYear "2000" @default.
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