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- W2372636568 abstract "OBJECTIVE:To evaluate the efficacy and toxicity of GP regimen(gemcitabine plus cisplatin)in the treatment of lung metastases from nasopharyngeal carcinoma.METHODS:Sixty-one patients with lung metastases from nasopharyngeal carcinoma were randomized into two groups.Group GP included 29 cases and was treated with gemcitabine plus cisplatin.Group PF included 32 cases and was treated with 5-Fluorouracil plus cisplatin.All of them were treated for 2 cycles.RESULTS:All patients were evaluated for the efficacy and toxicity.In group GP,complete responses(CR)cases were 5(17.2%),partial responses(PR)were 15(51.7%),stable disease(SD)were 7(24.1%)and progressive disease(PD)were 2(6.9%).In group PF,CR were 2(6.3%),PR were 11(34.4%),SD were 13(40.6%)and PD were 6(18.8%).The overall response rates were 69.0% in Group GP and 40.6% in Group PF,and there was a significant difference(χ2=4.921,P=0.027).In Group GP,the median survival time was 15 months,1-,2-,3-year survival rates were 63.9%,31.9% and 21.3%,respectively,and those of Group PF were 13 months,57.7%,19.2% and 9.6%,respectively.There was no statistical difference between the two groups(χ2=1.024,P=0.311).The common toxicity was nausea and vomiting,leucopenia and thrombocytopenia.There was no statistical diffevence between the two groups(P0.05).CONCLUSION:The regimen of gemcitabine plus cisplatin is an effective salvage regimen for lung metastases from nasopharyngeal carcinoma.The toxic side-effects were mild and tolerable." @default.
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- W2372636568 date "2009-01-01" @default.
- W2372636568 modified "2023-09-23" @default.
- W2372636568 title "Gemcitabine combined with cisplatin in treatment of lung metastases from nasopharyngeal carcinoma" @default.
- W2372636568 hasPublicationYear "2009" @default.
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