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- W2372639938 abstract "Objectives Torsade de pointes (TdP) is a life-threaten arrhythmia and the cellular mechanism of it is still questioned.The aim of this study is to investigate the arrhythmiasgenesis of transmural dispersion of repolarization (DOR) and triggered activity in LQT syndrome.Methods Optical mapping was used to measure transmural action potentials duration (APD) from the arterially perfused left ventricular canine wedge preparation.D-sotalol and ATX-Ⅱ were used to mimic LQT2 and LQT3,respectively.Each group included 6 preparations.Results The mean APD were(291±27)ms, (356±20) ms,(609±92) ms in control,LQT2,and LQT3 condition,respectively,(P0.05).The DOR were (24±6) ms,(35±9) ms,(121±85) ms in control,LQT2,and LQT3 group,(P0.05).All three kinds of myocardial cells had the potential to generate early afterdepolarization (EADs) .But it more likely occurred in endomyocardial cells and M cells.EAD-induced triggered activity often originated from M cells.Conclusions Inhomogeneous transmural action potential prolongation plays an important role in repolarization dispersion and provides the substrate for arrhythmiasgenesis.EADs and EAD-induced triggered activity are enhanced under conditions of prolonged APD and have also been shown to play an important role in the initiation of TdP." @default.
- W2372639938 created "2016-06-24" @default.
- W2372639938 creator A5083348128 @default.
- W2372639938 date "2004-01-01" @default.
- W2372639938 modified "2023-09-25" @default.
- W2372639938 title "Optical mapping of the transmural dispersion of repolarization and early after depolarization in LQT2 and LQT3 models of long QT syndrome" @default.
- W2372639938 hasPublicationYear "2004" @default.
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