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- W2372647845 abstract "This experiment was conducted to investigate the pharmacokinetics and bioavailability of marbofloxacin in healthy dogs.A single oral or i.v.administration of the drug at the dose of 2.75 mg·kg-1 to 8 dogs were performed in an open randomized crossover test.Blood samples were collected at different intervals after administration and concentrations of marbofloxacin were determined by HPLC method.The concentration-time date were analyzed with 3P97 computer program to get the pharmacokinetics parameters.The drug concentration-time data were fitted to a no absorbed two-compartment open model after i.v.administration in pigs.The main pharmacokinetic parameters were as follows T1/2α(0.34±0.14)h,T1/2β(7.74±1.70)h,V(1.03±0.60)L·kg-1,CL(0.22±0.08)L·h-1;AUC(14.05±4.25)mg·mL-1·h.The drug concentration-time data were fitted to a two-compartment model with first order absorption after single oral administration in dogs.The main pharmacokinectic parameters were as follows:T1/2α((2.82±1.86)h,T1/2β(16.03±9.27)h,V/F(2.25±0.34)L·kg-1,CL/F(0.21±0.05)L·h-1,Tmax(1.55±0.62)h,Cmax(0.89±0.21)μg·mL-1,AUC(13.66±2.77)mg·mL-1·h.Marbofloxacin was rapidly absorbed and the drug was completely absorbed after single oral administration and have a good bioavailability in dogs." @default.
- W2372647845 created "2016-06-24" @default.
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- W2372647845 date "2010-01-01" @default.
- W2372647845 modified "2023-09-27" @default.
- W2372647845 title "Bioavailability of Marbofloxacin in Dogs by Oral Administrate" @default.
- W2372647845 hasPublicationYear "2010" @default.
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