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- W2372649488 abstract "Aim:To study the impact of glutamine on the expression of Occludin in the intestinal mucosal tissue from the acute global cerebral ischemia-reperfusion(GCIR)injury rats.Methods:The global brain ischemia rat model was established through the four-vessel occlusion method.The rats were divided into four groups:the sham operation group(control group),the saline group,the ozagrel group and the glutamine group.The latter 3 groups were established GCIR model.The saline group was given the same volume normal saline time after reperfusion;the ozagrel group was given the same volume normal saline in which ozagrel 33.67 mg/kg was dissolved at the same time;the glutamine group was given the same volume normal saline in which ozagrel 33.67 mg/kg and 20%glutamine 0.4 g/kg were dissolved respectively.The time of observation was 6,12,24 h after reperfusion.After that,every experimental animal was killed,and brain and intestine were obtained to investigate the pathological changes of the neurons in the hippocampus with the HE staining and the expression of Occludin in the intestinal mucosa with the immunohistochemistry.Results:At 6,12,24 h after reperfusion,the struceture of hippocampus cells were disordered and the bondaries of them were indistinct in the saline group,the ozagrel group and the glutamine group.The expression of Occludin protein has significant difference among the 4 gorups at 12,24 h(H=15.175,20.234,P0.001).The expression of Occludin in the saline group,the ozagrel group and the glutamine group decreased than that in the sham operation group;the expression of Occludin in the glutamine group was higher than those in the saline group and the ozagrel group(P0.05).Conclusion:Glutamine can protect the intestinal mucosal barrier in the acute global cerebral ischemia-reperfusion injury in rats against the decrease of the expression of Occludin." @default.
- W2372649488 created "2016-06-24" @default.
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- W2372649488 date "2011-01-01" @default.
- W2372649488 modified "2023-09-26" @default.
- W2372649488 title "Impact of glutamine on expression of Occludin in intestinal mucosal tissue from acute global cerebral ischemia-reperfusion injury rats" @default.
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