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- W2372659980 abstract "Objective:To evaluate the effects of recombinant human IGF-1 and/or somatostatin-14 on the proliferation of cultured orbital fibroblasts of thyroid-associated ophthalmopathy(TAO) patients.Methods:Cultured orbital fibroblasts from 4 severe TAO patients were exposed to IGF-1 and/or SST-14 at various concentrations for 1,2,and 3d respectively.The proliferation of the cells was studied with MTT assay.Results:Compared with that of the control group,the proliferation of cultured orbital fibroblast was enhanced by IGF-1 at 50μg/L or higher concentrations,while it was inhibited by SST-14 at 5nmol/L or higher concentrations.These effects were in both dose-and time-dependant way.The promotive effect of IGF-1 at 100μg/L on cultured fibroblasts could be blocked by SST-14 at 50nmol/L or higher concentrations.Conclusion:IGF-1 can promote the proliferation of the cultured orbital fibroblast.SST-14 can inhibit the proliferation of the cells,and block the promotive effect of IGF-1.These findings suggest that SST-14 may decrease the proliferative effect of IGF-1 through postreceptor inhibition mechanism." @default.
- W2372659980 created "2016-06-24" @default.
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- W2372659980 date "2009-01-01" @default.
- W2372659980 modified "2023-09-24" @default.
- W2372659980 title "Effects of IGF-1 and Somatostatin-14 on the Proliferation of Cultured Orbital Fibroblasts of Thyroid-associated Ophthalmopathy Patients" @default.
- W2372659980 hasPublicationYear "2009" @default.
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