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- W2372676377 abstract "Objective To investigate the effects of telmisartan on oxidative stress in type 1 diabetic rats.Methods Type 1 diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) in adult male Wistar rats.Sixteen diabetic rats were randomly divided into two groups (8 each):diabetic mellitus group (DM) and telmisartan group (T).Eight normal rats were employed as the control group (Con group).After 12 weeks,body weight (BW) and heart weight (HW) were measured to calculate HW/BW.Glutathione (GSH),malondialdehyde (MDA),the activity of superoxide dismutase (SOD) were evaluated by spectrophotometer.Ultrastructure of myocardial cells was observed by transmission electron microscope.Results There was no significant difference in blood glucose levels between DM group and T group at the 7th day and 12th week after STZ injection,but the blood glucose levels in the both groups were significantly higher than that in Con group (P0.01).Compared with Con group,the MDA level was significantly elevated,GSH level and the activity of SOD significantly lowered in DM group (P0.01),while no significant difference in serum GSH level was found between T group and Con group (P0.05).The MDA level was higher (P0.05) and the activity of SOD was significantly lower in T group than that in Con group (P0.01).Compared with DM group,the GSH level and the activity of SOD were remarkably higher in T group (P0.01),meanwhile,the MDA level in T group was lower than that in DM group (P0.01).Ultrastructure observation of myocardial cell showed that myocardial fibers arranged regularly,mitochondrial membrane was integral,and no swelling or degeneration was observed in Con group.Myocardial cell of DM group was characterized by swollen mitochondria with irregularly arranged or broken and even dissolved mitochondrial crista.In addition,vacuolar degeneration was observed remarkably in myocardial mitochondria.The ultrastructural injury to myocardial cells was obviously alleviated in T group compared with DM group.Conclusion Telmisartan may inhibit oxidative stress,and improve the ultrastructure of myocardial cells in type 1 diabetic rats." @default.
- W2372676377 created "2016-06-24" @default.
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- W2372676377 date "2010-01-01" @default.
- W2372676377 modified "2023-09-23" @default.
- W2372676377 title "Effect of telmisartan on oxidative stress in type 1 diabetic rats" @default.
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