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- W2372689557 abstract "AIM In order to inquire the toxic mechanism of allyl chloride(AC). METHODS Thirty Wistar male rats were treated by sc AC 100 mg·kg -1 ·d -1 (low dose group, LD) or 200 mg·kg -1 ·d -1 (high dose group, HD) for 90 d and the percent content changes in low molecular weight neurofilament(NF L), middle molecular weight neurofilament(NF M), and high molecular weight neurofilament(NF H) in cerebrum, spinal cord and sciatic nerve were analyzed by Western blot. RESULTS In cerebrum precipitant and supernatant, neurofilament three subunits were all decreased significantly in LD (n =10, P 0.01) and HD (n=10, P0.01); in spinal cord precipitant and supernatant, NF M decreased significantly (n=10, P0.01); NF H increased significantly in precipitant (n=10, P0.01), but decreased in supernatant; NF L increased in precipitant. In sciatic nerve, NF M were reduced, however, NF H enhanced. NF L decreased in precipitant, but increased in supernatant. CONCLUSION The results suggest that AC induced peripheral neuropathy be related to NF subunit contents disturbed." @default.
- W2372689557 created "2016-06-24" @default.
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- W2372689557 date "2002-01-01" @default.
- W2372689557 modified "2023-09-25" @default.
- W2372689557 title "Effect of allyl chloride on the content of neurofilament protein in rat" @default.
- W2372689557 hasPublicationYear "2002" @default.
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