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- W2372693105 abstract "Objective:To investigate the regulatory effects of nitric oxide(NO) and angiotensin II(Ang II) on myocardial ischemia and the expression of vascular endothelial growth factor in rats.Methods: Thirty Sprague-Dawley rats were randomized into five groups(n=6 each),including the control group(COL,group A),the isoproterenol group(ISO,group B),the isoproterenol + losartan group(LOS,group C),the isoproterenol + N-nitro-L-arginine group(L-NNA,group D) and the isoproterenol + losartan + N-nitro-L-arginine group(LOS+L-NNA,group E).Acute myocardial ischemia model was induced with isoproterenol(ISO).N-nitro-L-arginine(L-NNA) was used to block the nitric oxide synthase(NOS),as was losartan(LOS) to block the AT1 receptor.Cardiac function was measured with a BL-420 biological signal processing system,contents of NO and creatine kinase(CK) measured by biochemistry methods,myocardial injury studied by HE stained histopathology,and expressions of VEGF and endothelial nitric oxide synthase(eNOS) analyzed by immunohistochemistry.RT-PCR was employed to detect the VEGF mRNA and eNOS mRNA in myocardium.Results: Compared with groups B,D and E,group C showed improved cardiac functions,attenuated myocardial damages(P0.01) and increased content of nitric oxide(P0.01).Enhanced expressions of VEGF mRNA and protein were also noted in C group compared with the other groups(P0.01).The levels of eNOS mRNA and protein expression were higher in groups C and E than in groups C and D(P0.01).Conclusion: Blockade of Ang II type 1 receptor was shown to up-regulate VEGF expression in rat myocardium.Nitric oxide and angiotensin II type 1 receptor signaling pathway may be playing a critical role in regulating VEGF expression.Losartan appeared protective for myocardium partly due to its regulation on VEGF and eNOS expressions and nitric oxide activity." @default.
- W2372693105 created "2016-06-24" @default.
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- W2372693105 date "2007-01-01" @default.
- W2372693105 modified "2023-09-24" @default.
- W2372693105 title "Regulatory Effects of Nitric Oxide and Angiotensin II on Myocardial Ischemia and Expression of Vascular Endothelial Growth Factor in Rats" @default.
- W2372693105 hasPublicationYear "2007" @default.
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