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- W2372728803 abstract "Objective To observe the effect of different doses of simvastatin on the inflammatory factors,serum lipid and the atherosclerosis regression in acute myocardial infarction patients.Methods Forty-three patients with acute myocardial infarction were divided into 2 groups(A,B group).The patients in group A(22 patients)were given orally simvastatin 20 mg/d,and the patients in group B(21 patients)were given orally simvastatin 40 mg/d.The serum level of high sensitivity C reactive protein(hs-CRP),soluble CD40 ligand(sCD40L),matrix metalloproteinase-9(MMP-9) and serum lipid were measured at the end of the 12th week and the 24th week.The carotid IMT and plaque score were measured at the end of the 24th week and the 48th week.Results In group A and group B patients,their serum levels of hs-CRP,sCD40L,MMP-9 and serum lipid were significantly decreased at the end of the 12th and the 24th week(P0.05),and group B(simvastatin 40 mg/d) was superior to group A(simvastatin 20 mg/d)(P0.05).The carotid IMT and plaque score in both groups tended to decrease at the end of the 48th week,and group B(simvastatin 40 mg/d) was superior to group A(simvastatin 20 mg/d,P0.05).Conclusions When the acute myocardial infarction patients were treated early with simvastatin,the serum levels of inflammatory factors and serum lipid were significantly decreased,the progression of atherosclerosis might be inhibited to some extent,and the high dose of simvastatin might be better." @default.
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- W2372728803 date "2008-01-01" @default.
- W2372728803 modified "2023-09-23" @default.
- W2372728803 title "The effect of different doses of simvastatin on the inflammatory markers and serum lipid in acute myocardial infarction patients" @default.
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