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- W2372738419 abstract "Objective:To explore the relationship between the polymorphisms of 19 locus,43 locus,and 63 locus in CAPN-10 gene and genetic susceptibility of gestational diabetes mellitus(GDM). Methods:Case-control study and PCR-RFLP technique were used for genotyping of 19 locus,43 locus,and 63 locus in CAPN-10 gene of 100 pregnant women with normal glucose tolerance(NGT)(NGT group),100 patients with gestational impaired glucose tolerance(GIGT)(GIGT group),and 100 patients with GDM(GDM group). Results:The frequencies of genotypes of 19 locus,43 locus,and 63 locus in CAPN-10 gene were detected by Hardy-Weinberg equation law,all of them were coincidence with genetic equation law,which indicated that all the frequencies of genotypes satisfied genetic equation(P0.05),the distribution of genotyping frequency had colonial representativeness.The frequencies of GG genotype and C allele in 43 locus in GDM group were significantly higher than those in NGT group(P0.05),but there was no significant difference between GIGT group and NGT group.In GDM group,GIGT group,and NGT group,there was no significant difference in the frequencies of genotype and allele between 19 locus and 63 locus;there was no significant difference in the frequencies of genotype and allele in 19 locus,43 locus,and 63 locus between GIGT group and GDM group. Conclusion:Polymorphism of CAPN-10 gene may be correlated with genetic susceptibility of GDM;G allele in SNP43 locus of CAPN-10 gene may be related to the occurrence of GDM,but 16 locus and 63 locus are not correlated with the occurrence of GDM." @default.
- W2372738419 created "2016-06-24" @default.
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- W2372738419 date "2012-01-01" @default.
- W2372738419 modified "2023-09-24" @default.
- W2372738419 title "Relationship between polymorphism of CAPN-10 gene and genetic susceptibility of gestational diabetes mellitus" @default.
- W2372738419 hasPublicationYear "2012" @default.
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