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- W2372740978 abstract "Objective To evaluate the effect and safety of anticoagulant citrate dextrose solution A (ACD-A ) in continuous blood purification (CBP) for patients at high risk of bleeding with ARF. Methods Twelve patients at high risk of bleeding, treated with continuous venovenous hemofiltration(CVVH), were divided into regional citrate anticoagulant (RCA) group and control group. In the former, ACD-A solution was delivered, pre-filter , with the rate adjusted to maintain a postfilter ionized calcium (iCa2+) level between 0.30-0.40 mmol/L. Before the extracorporeal blood returned to the patient, 10% calcium gluconate was infused to maintain a systemic iCa2+ level between 0.90-1.20 mmol/L. In control group, CVVH were performed either with low dose of heparin LMW sodium (1700-2500 IU/12 h-24 h)or without anticoagulant. The life span of each hemofilter was recorded. In RCA group, prothrombin time (PT), activated partial thromboplastin time (APTT) , acid-base changes, serum sodium and iCa2+ were monitored pre- and during CVVH. Result In the whole duration 1192.5 hours of CVVH in RCA group and 596 hours in control group, 62 and 42 hemofilters were used, respectively. Filter survival was 65.3% at 24 h and 24.5% at 48 h in RCA group,while 14.5% and 0 in control group. The mean life span of filter in RCA group was significantly longer than that in control group[(29.4±21.0) (1.5-71.5)h vs( 14.2±8.2) (4.5-40)h, P 0.01]. During 38 sessions of CVVH with ACD-A solution anticoagulation, PT, APTT, acid-base status,serum iCa2+ and sodium showed subtle changes, compared with pre-CVVH.There were no significant bleeding events and no muscular spasms induced by ACD-A solution. Conclusion ACD- A solusion as anticoagulant during CBP is safe, convenient and effective for patients at high risk of bleeding with ARF." @default.
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- W2372740978 date "2006-01-01" @default.
- W2372740978 modified "2023-09-25" @default.
- W2372740978 title "ACD-A solution as anticoagulant in continuous blood purification for patients at high risk of bleeding" @default.
- W2372740978 hasPublicationYear "2006" @default.
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