Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372742017> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2372742017 abstract "Objective To investigate the effects of hydroxy safflor yellow A(HSYA)on contractile function of left ventricle of isolated rat heart.Methods Forty-two rats were randomly divided into control group,HSYA(1-100 μmol/L)group,HSYA(30 μmol/L)control group,HSYA(30 μmol/L)+glibenclamide(Gli)group,HSYA(30 μmol/L)+tetraethylammonium(Tea)group,HSYA(30 μmol/L)+4-aminopyridine(4-AP)group and HSYA(30 μmol/L)+atropine(Art)group,with 6 rats in each group.Langendorff perfused heart preparation was made,and the isolated hearts were perfused with HSYA in a stepwise fashion.The effects on contractile function of left ventricle before and after treatment with different concentrations of HSYA were observed by PowerLab system from a fluid filled latex balloon in the left ventricle.The influence of different types of K+ channel blockers on the effects of HSYA was also observed.ResultsHSYA reduced left ventricular systolic pressure,left ventricular end-diastolic pressure,maximum rate of increase of left ventricular pressure and heart rate in a dose-dependent manner(P0.05 or P0.01),while had no significant effect on maximum rate of decrease of left ventricular pressure(P0.05).Gli and Tea blocked the effects of HSYA in a concentration-dependent manner(P0.05 or P0.01),but 4-AP and Art did not block the effects of HSYA(P0.05).Conclusion HSYA could significantly decrease the myocardial contractility and heart rate in a dose-dependent manner,and its action mechanism might be related to the opening of ATP sensitivity K+ channel and Ca2+ dependent K+ channel." @default.
- W2372742017 created "2016-06-24" @default.
- W2372742017 creator A5037143491 @default.
- W2372742017 date "2010-01-01" @default.
- W2372742017 modified "2023-09-26" @default.
- W2372742017 title "Effects of hydroxy safflor yellow A on cardiac function of isolated hearts" @default.
- W2372742017 hasPublicationYear "2010" @default.
- W2372742017 type Work @default.
- W2372742017 sameAs 2372742017 @default.
- W2372742017 citedByCount "0" @default.
- W2372742017 crossrefType "journal-article" @default.
- W2372742017 hasAuthorship W2372742017A5037143491 @default.
- W2372742017 hasConcept C126322002 @default.
- W2372742017 hasConcept C134018914 @default.
- W2372742017 hasConcept C146957229 @default.
- W2372742017 hasConcept C164705383 @default.
- W2372742017 hasConcept C178790620 @default.
- W2372742017 hasConcept C178853913 @default.
- W2372742017 hasConcept C185592680 @default.
- W2372742017 hasConcept C26635844 @default.
- W2372742017 hasConcept C2777953023 @default.
- W2372742017 hasConcept C2778921608 @default.
- W2372742017 hasConcept C2779768347 @default.
- W2372742017 hasConcept C2781295685 @default.
- W2372742017 hasConcept C39133596 @default.
- W2372742017 hasConcept C48277249 @default.
- W2372742017 hasConcept C517785266 @default.
- W2372742017 hasConcept C555293320 @default.
- W2372742017 hasConcept C71924100 @default.
- W2372742017 hasConcept C84393581 @default.
- W2372742017 hasConcept C98274493 @default.
- W2372742017 hasConceptScore W2372742017C126322002 @default.
- W2372742017 hasConceptScore W2372742017C134018914 @default.
- W2372742017 hasConceptScore W2372742017C146957229 @default.
- W2372742017 hasConceptScore W2372742017C164705383 @default.
- W2372742017 hasConceptScore W2372742017C178790620 @default.
- W2372742017 hasConceptScore W2372742017C178853913 @default.
- W2372742017 hasConceptScore W2372742017C185592680 @default.
- W2372742017 hasConceptScore W2372742017C26635844 @default.
- W2372742017 hasConceptScore W2372742017C2777953023 @default.
- W2372742017 hasConceptScore W2372742017C2778921608 @default.
- W2372742017 hasConceptScore W2372742017C2779768347 @default.
- W2372742017 hasConceptScore W2372742017C2781295685 @default.
- W2372742017 hasConceptScore W2372742017C39133596 @default.
- W2372742017 hasConceptScore W2372742017C48277249 @default.
- W2372742017 hasConceptScore W2372742017C517785266 @default.
- W2372742017 hasConceptScore W2372742017C555293320 @default.
- W2372742017 hasConceptScore W2372742017C71924100 @default.
- W2372742017 hasConceptScore W2372742017C84393581 @default.
- W2372742017 hasConceptScore W2372742017C98274493 @default.
- W2372742017 hasLocation W23727420171 @default.
- W2372742017 hasOpenAccess W2372742017 @default.
- W2372742017 hasPrimaryLocation W23727420171 @default.
- W2372742017 hasRelatedWork W2043201738 @default.
- W2372742017 hasRelatedWork W2092762304 @default.
- W2372742017 hasRelatedWork W2094456553 @default.
- W2372742017 hasRelatedWork W2103659193 @default.
- W2372742017 hasRelatedWork W2358643794 @default.
- W2372742017 hasRelatedWork W2395444243 @default.
- W2372742017 hasRelatedWork W2397642262 @default.
- W2372742017 hasRelatedWork W2401234871 @default.
- W2372742017 hasRelatedWork W2419097303 @default.
- W2372742017 hasRelatedWork W2444692313 @default.
- W2372742017 hasRelatedWork W2460476290 @default.
- W2372742017 hasRelatedWork W2982992440 @default.
- W2372742017 hasRelatedWork W2983036052 @default.
- W2372742017 hasRelatedWork W2992248717 @default.
- W2372742017 hasRelatedWork W3029201377 @default.
- W2372742017 hasRelatedWork W3030011923 @default.
- W2372742017 hasRelatedWork W3032069491 @default.
- W2372742017 hasRelatedWork W3032223099 @default.
- W2372742017 hasRelatedWork W3081688141 @default.
- W2372742017 hasRelatedWork W3132904421 @default.
- W2372742017 isParatext "false" @default.
- W2372742017 isRetracted "false" @default.
- W2372742017 magId "2372742017" @default.
- W2372742017 workType "article" @default.