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- W2372743297 abstract "OBJECTIVE:To discuss mechanism of miRNA-128-1 expression in HEK293 cells and lay the foundation for further study of miRNA-128-1 regulation in glioma.METHODS:Through analyzing UCSC,we found the probable miRNA-128-1 promoter area.We used UCSC and CBIL to obtain the predicted transcription factors binding on the miRNA-128-1 promoter area.Related plasmids were constructed,including pB-miRNA-128-1 promoter, pShNFl,pShc-Myc,pShTAF1,pShYY1,pShMAF,PShRELA2,pShRNUXl and pShNFkappaB.Cotransfecting pB-miRNA-128-1 promoter and pShRNA into HEK293 cells,we analyzed luciferase activity to identify probable transcription factors which could regulate miRNA-128-1 promoter activity.RESULTS:pShc-Myc suppressed the activity of pB-miRNA-128-1 promoter.pShNFkappaB increased the activity of pB-miRNA-128-1 promoter dramatically.pShNF1,pShTAF1,pShYY1,pShMAF,PShRELA2 or pShRNUX1 showed no obvious influence on the expression of pB-miRNA-128-1.CONCLUSION:In HEK 293 cells,c-Myc upregulated whilst NFkappaB downregulated the promoter activity of miRNA-128-1." @default.
- W2372743297 created "2016-06-24" @default.
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- W2372743297 date "2012-01-01" @default.
- W2372743297 modified "2023-09-25" @default.
- W2372743297 title "The mechanism of miRNA-128-1 expression in HEK293 cells" @default.
- W2372743297 hasPublicationYear "2012" @default.
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