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- W2372747510 abstract "Objective To detect the methylation of APC gene promoter in plasma from lung tumor patients and determine its meaning in early lung cancer diagnosis.Methods Plasma was collected from 92 patients with lung solid tumor diagnosed by CT-guided punctuation and 23 healthy volunteers.All the 92 patients,in whom 58 were lung cancer,31 were benign lung disease and 3 were indefinite diagnosis,were confirmed by histology.Plasma DNA was extracted by Chemagic Viral DNA/RNA kit.Real-time MSP was used to detect the methylation of APC gene promoter after bisulfite modification.Results In 58 lung cancer patients 11 cases were positive(11/58,19%),but no positive case was found in the other patients(31 benign lung disease,3 indefinite diagnosis) or healthy controls.Conclusions The detection of APC gene promoter methylation in plasma by the real-time MSP may be useful in the early diagnosis of lung cancer." @default.
- W2372747510 created "2016-06-24" @default.
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- W2372747510 date "2008-01-01" @default.
- W2372747510 modified "2023-09-23" @default.
- W2372747510 title "Detection of APC gene promoter methylation in plasma of early lung cancer" @default.
- W2372747510 hasPublicationYear "2008" @default.
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