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- W2372759863 abstract "[Objective]To investigate the effect of recombinant staphylokinase(r-Sak)on severe acute pancreatitis(SAP) and severe acute pancreatitis associated myocardial damage.[ Methods]: Sixty-three male SD rats were divided randomly into the sham-operated group(group A,n=9),the control group(group B,n=27) and the r-Sak treatment group(group C,n=27).SAP was induced by intraductal administration 5 % sodium taurocholate.Artery blood of group A,B and C was obtained at 6h,12h and 18h after induction of the model.Serum contents of TNFα,IL-6 and CK-MB,CTn1 were detected with ELISA.The activity of NF-κB in myocardial tissue was determined by SP immunohistochemical technique.Pancreatic and myocardial tissues were examined under light and electron microscopy. [Result]:The contents of CTn1,CK-MB in serum was significantly increased in 6 hours after induction of SAP,and the serum levels of TNF-α and IL-6 were also elevated at the same time.The contents of the CTn1,CK-MB and TNF-α,IL-6 in serum were significantly decreased,compared with those of the control group(P0.05).The pathological changes of pancreatic and myocardial tissues in the treatment group were alleviated in contrast to the control group.[Conclusion]:R-Sak can lighten the pathological changes of SAP rats,and alleviate myocardial damage following SAP.R-Sak is a promising agent for SAP therapy and the application of thrombolytic agents would be a new strategy for SAP therapy." @default.
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- W2372759863 date "2006-01-01" @default.
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- W2372759863 title "Effect of recombinant staphylokinase on inhibiting rats' myocardial damage following severe acute pancreatitis" @default.
- W2372759863 hasPublicationYear "2006" @default.
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