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- W2372765008 abstract "Kruppel-like factor 5(KLF5) is a member of the Sp/KLF family of zinc finger factors.KLF5 is a key transcriptional factor of cardiovascular remodeling.In this study,we investigated whether KLF5 was involved in Ang Ⅱ-induced proliferation in vascular smooth muscle cells(VSMCs).The MTT assays showed that Ang Ⅱ treatments led to an increase of VSMCs proliferation.Western blotting and RT-PCR showed that Ang Ⅱ dose-dependently induced the expression of KLF5 and c-Jun at both protein and mRNA levels.Knock-down of endogenous KLF5 expression with KLF5-specific small interfering RNA(siRNA) abrogated the induction of Ang Ⅱ on VSMC proliferation.The interaction between KLF5 and c-Jun was subsequently verified by cross-coimmunoprecipitation and GST pull-down assays.Ang Ⅱ stimulation enhanced the association of KLF5 with c-Jun.These findings suggested that KLF5 plays an important role in Ang Ⅱ-induced proliferation by interacting with c-Jun in VSMCs." @default.
- W2372765008 created "2016-06-24" @default.
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- W2372765008 date "2011-01-01" @default.
- W2372765008 modified "2023-09-28" @default.
- W2372765008 title "Interaction between KLF5 and c-Jun Promotes Ang II-induced VSMC Proliferation" @default.
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