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- W2372765185 abstract "Objective To investigate the clinical value of fluorescent in situ hybridization ( FISH) during prenatal diagnosing.Methods The interphase nuclei of amniotic fluid from 116 pregnant women with 16-23 gestational weeks were detected by chromos-specific DNA probes of 13,18,21,X and Y-chromosomes.The routine analysis of amniotic cells karyotypes was also performed at same time.Results Normal chromosome karyotypes were shown in 108 cases and chromosome abnormality was found in 6 cases,respectively,by FISH technique.These results were consistent with those obtained by routine analysis of amniotic cell chromosome karyotypes.The chromosome karyotype of balance transposal and inner inverse abnormity was found in 1 case,respectively,whose FISH signal showed normal.Conclusion FISH technique for prenatal diagnosis showed simple,rapid and high specific characters etc,but there were some limits.FISH technique should combine with routine analysis of chromosome karyotype when more reliable information was provided for the clinical diagnosis." @default.
- W2372765185 created "2016-06-24" @default.
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- W2372765185 date "2010-01-01" @default.
- W2372765185 modified "2023-09-23" @default.
- W2372765185 title "Rapid prenatal diagnosis for fetal chromosomes abnormality by fluorescent in situ hybridization(FISH)" @default.
- W2372765185 hasPublicationYear "2010" @default.
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