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- W2372765863 abstract "Objective To investigate the radioprotective effects of resveratrol(RES) on the recovery of hematopoiesis in irradiation-injured mice.Methods Thirty male ICR mice were randomized into 5 groups,including normal control group,irradiated control group,RES 50 mg · kg-1 irradiated group,RES 100 mg · kg-1 irradiated group and RES 200 mg · kg-1 irradiated group.RES was administered respectively to three dosage groups by gavage for 3 days before irradiation.Except for normal control,all mice were whole-body irradiated by 60Co γ ray(a single dose of 5.5 Gy).The mice were killed on 7th day after irradiation.The number of bone marrow mononuclear cells(BMNC) and colony forming units-spleen(CFU-S) was counted.The content of DNA of marrow cells and and cell cycles of bone marrow cell were measured.Results Compared with normal control group,the number of bone marrow mononuclear cells(BMNC) and the content of DNA of marrow cells were significantly decreased(P0.05) and the phase S and G2/M marrow cell percentage and the number of CFU-S were significantly increased in irradiated control group mice(P0.05).Compared with irradiated control,the number of bone marrow mononuclear cells(BMNC),the content of DNA of marrow cells,the phase S and G2/M marrow cell percentage and the number of CFU-S were significantly increased in 100 and 200 mg · kg-1 RES irradiated groups(P0.05).There were similar changes in 50 mg · kg-1 RES irradiated groups.Conclusion RES can promote the recovery of hematopoietic system injury in 60Coγ rays irradiated mice and the radioprotective effects of RES are correlated with the dosage." @default.
- W2372765863 created "2016-06-24" @default.
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- W2372765863 date "2013-01-01" @default.
- W2372765863 modified "2023-09-28" @default.
- W2372765863 title "Study on Radioprotective Effect of Resveratrol on Recovery of Hematopoiesis in Irradiation-injured Mice" @default.
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