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- W2372767931 abstract "Objective To investigate the serological characteristics of damaged liver in patients with chronic liver diseases caused by hepatitis B virus(HBV) and hepatitis C virus(HCV) coinfection.Methods 225 samples of liver biopsy in patients with chronic liver diseases(including chronic hepatitis B,chronic hepatitis C,chronic hepatitis or cirrhosis induced by HBV and HCV coinfection,post-hepatitis cirrhosis) were collected through needle aspiration in our hospital.The liver function,sera HBVDNA,HBV sera markers,sera HCVRNA and anti-HCV in all cases were detected routinely.All liver specimens were fixed in a 10% neutral formalin,embedded in paraffin and stained with hematoxylin-eosin.The hepatitis was staged and graded.HBSAg and HBCAg in livers were detected by immunohistochemical technique,HBVDNA and HCVRNA in liver were detected by in situ hybridizationliver. Results ① In patients with severe chronic hepatitis:those coinfected with HBV and HCV(B plus C group) had similar or lower levels of glutamate pyruvate transaminase(ALT),glutamate oxalo-acetate transaminase(AST),total bilirubin(TB) and direct bilirubin(DB) as compared with those infected with HCV(group C)(P0.05) or HBV(group B)(P0.05) alone, respectively.② In patients suffered from non-severe chronic hepatitis:the serological changes of damaged liver did not differ significantly among the three groups.③The age of patients in group C and B plus C group were similar(P0.05),but patients in these two groups were older than those in group B(P0.01).④ The clinical duration of disease in those infected with either HBV or HCV were similar(P0.05),but they have longer duration of disease than those coinfected with HBV and HCV,and the latter have shorter disease duration to develop to severe hepatitis(P0.01). Conclusion In patients with severe chronic hepatitis,the serological changes of indexes(ALT,AST,TB and DB) can not used as markers to evaluate the severity of liver damage.As compared with those infected with HCV or HBV alone,respectively,patients coinfected with HBV and HCV have shorter duration to develop to severe hepatitis." @default.
- W2372767931 created "2016-06-24" @default.
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- W2372767931 date "2010-01-01" @default.
- W2372767931 modified "2023-09-26" @default.
- W2372767931 title "The serological characteristics of damaged livers in patients with chronic HBV and HCV coinfection" @default.
- W2372767931 hasPublicationYear "2010" @default.
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