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- W2372777881 abstract "Objective To compare the effect of general anesthesia combined with epidural anesthesia versus single general anesthesia on postoperative cognitive function and central nerve injury in gerontal patients undergoing thoracic surgery. Methods Sixty elderly patients scheduled for thoracic surgery were randomly divided into general anesthesia group and general anesthesia combined with epidural anesthesia group (n=30). Mini-mental state examination (MMSE)was used to all patients 1day before surgery, and 1,3, 7 and 28 days after surgery. Venous blood was taken to measure the concentration of S100β and neurone specific enolase (NSE) in plasma 1day before surgery, at the end of surgery, and 1 day after surgery. Results The MMSE score of general anesthesia combined with epidural anesthesia group was significantly higher than general anesthesia group at 1,3 and 7 days after surgery (all P0.05). Compared with preoperative score, postoperative MMSE score of two groups were significantly decreased (both P0.05). The concentration of S100β at the end of surgery and 1 day after surgery and NSE at the end of surgery in general anesthesia combinedwith epidural anesthesia groupwas significantly lower than those in general anesthesia group (all P0.05). Comparedwith preoperative levels, postoperative S100β and NSE of two groups were significantly increased (all P0.05). Therewas no significant difference in MMSE score between the two groups before surgery or 28 days after surgery (all P0.05). Neither were the concentrations of S100β and NSE before surgery, or NSE 1 day after surgery (all P0.05). Conclusion Compared to general anesthesia, general anesthesia combined with epidural anesthesia in thoracic surgery is more beneficial to the cognitive function for gerontal patients. (Shanghai Med J,2013,36:304-306)" @default.
- W2372777881 created "2016-06-24" @default.
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- W2372777881 date "2013-01-01" @default.
- W2372777881 modified "2023-09-26" @default.
- W2372777881 title "Influence of two different anaesthesia methods on central nerve injury and cognitive function after thoracic surgery in gerontal patients" @default.
- W2372777881 hasPublicationYear "2013" @default.
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