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- W2372781103 abstract "Background and purpose:Studies have shown that Toll-like receptor-4(TLR4) is associated with invasion and metastasis of various tumor types.However,its?mechanism?has not been elucidated and its?relationship?with?pancreatic cancer?needs further study.This study was aimed to investigate the correlation of TLR4 expression with invasion and metastasis of pancreatic cancer,and to analyze the underlying mechanism.Methods:Fifty-nine resected human pancreatic adenocarcinoma specimens and 30 para-carcinoma normal pancreatic tissues were used to detect the TLR4 and matrix metalloproteinase-9(MMP-9) protein expression by immunohistochemical methods.The correlations among TLR4 protein expression,MMP-9 protein expression and clinicopathologic feature of the patients were analyzed.After stimulated with lipopolysaccharide(LPS),MMP-9 protein expression of human?pancreatic cancer cell?lines PNAC-1 was examined by Western blot and the invasion ability of pancreatic cancer cells was evaluated by Transwell invasion chamber assay.Results:TLR4 and MMP-9 protein positive expression rates in pancreatic adenocarcinoma were 72.9% and 69.5% respectively,which were significantly higher than those in normal pancreatic tissue(P0.01).TLR4 protein expression was closely related to TNM stage,lymph node metastasis and MMP-9 protein expression was significantly correlated with tumor differentiation,TNM stage and lymph node metastasis(P0.05).The Spearman rank correlation test showed that there was a strong correlation between TLR4 and MMP-9 protein expression(P0.01).Compared with the normal group,the invasive cells number of PANC-1 was significantly increased after stimulated with LPS(P0.01).After stimulated with LPS for?6,12 and 24?h,?MMP-9 protein?relative expressions in?PANC-1?cells?were significantly higher than those in?the?normal group(P0.01).Conclusion:TLR4 protein?expression?is?closely related?to?invasion and metastasis?of pancreatic cancer,?and its?mechanism is related to promoting?MMP-9 protein?expression." @default.
- W2372781103 created "2016-06-24" @default.
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- W2372781103 date "2012-01-01" @default.
- W2372781103 modified "2023-09-25" @default.
- W2372781103 title "Correlation of TLR4 expression with invasion and metastasis of pancreatic cancer" @default.
- W2372781103 hasPublicationYear "2012" @default.
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