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- W2372794920 abstract "Objective To investigate blood lactic acid change and antiviral agent effect of nucleoside agent on patients with chronic severe hepatitis B. Methods 30 cases of chronic hepatitis B were retrospectively analyzed,and the blood lactic acid and MELD scores were detected and calculated. All the patients were divided into two groups according to admission order by treating with LAM and ETV respectively,and the change of blood lactic acid and MELD scores were observed. Results With the increase of blood lactic acid in patients with chronic hepatitis B of severe grade,the MELD scores were also increased( P 0. 05). After treatment,blood lactic acid in both groups was slightly higher than that before treatment( P 0. 05),while there was no significant difference on blood lactic acid and MELD scores between the two groups after treatment( P 0. 05). Case analysis showed that blood lactic acid was still largely moderately increasing,yet without any case of lactic acid poisoning. Conclusions Obvious correlation exists between MELD score and blood lactic acid. Combined application is of great significance for illness judgment. Application of nucleoside antiviral drugs can lead to moderate increase of blood lactic acid,therefore,clinical use should be based on benefit-risk balance and focus on surveillance." @default.
- W2372794920 created "2016-06-24" @default.
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- W2372794920 date "2014-01-01" @default.
- W2372794920 modified "2023-09-25" @default.
- W2372794920 title "Change of blood lactic acid and effect of antiviral agent of nucleoside in patients with chronic severe hepatitis B" @default.
- W2372794920 hasPublicationYear "2014" @default.
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