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- W2372804542 abstract "OBJECTIVE To retrospectively review the outcomes of nasopharyngeal carcinomas treated with intensity-modulated radiotherapy(IMRT)using a whole-field simultaneous integrated-boost technique(WF-SIB).METHODS Between Oct.2005 and Nov.2009,42 pathologically proved,non-metastasis patients treated with IMRT were eligible in this study.The distribution of disease was Stage I to IIB in 13 cases,Stage III to IVb in 29 cases.We prescribed 70-80.5 Gy and 62.7-70.0 Gy delivered in 33-35 fractions at the gross target volumes(GTV)and clinical target volumes 1(CTV1)respectively,and 50.4Gy delivered in 28 fractions at the clinical target volumes 2(CTV2).Twelve patients who suspected residual disease at the end of IMRT received a fractionated stereotactic boost,5-18.9 Gy.Normal tissue effects were graded according to the Radiation Therapy Oncology Group(RTOG)radiation morbidity scoring criteria.Local control rate(LC),regional control rate(RC),distant metastasis free survival(DMFS)and overall survival rate(OS)were estimated by Kaplan-Meier method.RESULTS The median follow-up period was 32 months(range 12-63 months).The 4-year estimates of LC,RC,DMFS and OS rate were 93.0%,97.4%,74.0%,and 82.2%,respectively.Acute toxicity was mostly grade 1 to grade 2 of mucositis and salivary gland reaction(90.5% and 85.7% respectively).Late toxicity was mainly grade 1 of xerostomia(47.6%).CONCLUSION WF-SIB intensity-modulated radiotherapy for untreated nasopharyngeal carcinomas not only improve the targets volume coverage,but also significantly spare of the salivary gland and nearby normal structures.IMRT results in good local-regional control rate and lower grade 3 to 4 side effects.The patterns of failure are mainly distant metastasis." @default.
- W2372804542 created "2016-06-24" @default.
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- W2372804542 date "2011-01-01" @default.
- W2372804542 modified "2023-09-26" @default.
- W2372804542 title "Clinical results of whole-field simultaneous integrated-boost intensity-modulated radiotherapy for untreated nasopharyngeal carcinoma" @default.
- W2372804542 hasPublicationYear "2011" @default.
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