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- W2372807269 abstract "Objective: To investigate the inhibitory effect of adenovirus-mediated IL-24(Ad-IL-24) on human glioma U87MG cells and to explore the underlying molecule mechanism.Methods: U87MG cells were infected with Ad-IL-24 constructed in our department,and IL-24 gene expression in U87MG cells was detected by RT-PCR.The growth and apoptosis of U87MG cells were examined by MTT and flow cytometry;the morphological change of U87MG cells was observed by laser scanning confocal microscopy;the Bax and Bcl-2 mRNA expressions were analyzed by RT-PCR;and the activation of caspase-3 was examined by Western blotting analysis.Results: The IL-24 gene was expressed in Ad-IL-24-infected U87MG cells.Ad-IL-24-infection inhibited the growth and induced apoptosis of U87MG cells,which showed typical morphological changes of apoptotic nuclei.Moreover,Ad-IL-24 increased Bax and decreased Bcl-2 mRNA expression,and induced caspase-3 activation in U87MG cells.Conclusion: Ad-IL-24 can induce apoptosis of U87MG cells,probably through up-regulating Bax expression,down-regulating Bcl-2 expression,and inducing caspase-3 activation." @default.
- W2372807269 created "2016-06-24" @default.
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- W2372807269 date "2010-01-01" @default.
- W2372807269 modified "2023-09-24" @default.
- W2372807269 title "Adenovirus-mediated IL-24 gene induces apoptosis of human glioma U87MG cells" @default.
- W2372807269 hasPublicationYear "2010" @default.
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