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- W2372847147 abstract "Objective To assess efficacy and safety of insulin detemir versus NPH insulin treatment as add-on therapy to previous oral antidiabetic therapy for type 2 diabetes.Methods 80 Patients with type 2 diabetes inadequately controlled were randomized to addition of once-daily insulin detemir versus NPH insulin for 16 weeks.Insulin doses were titrated toward prebreakfast glucose targets≤6.0mmol/L. Outcome measures included fasting blood glucose(FBG),HbA_1c,events of hypoglycemia,and body weight.Result After 16 weeks of treatment,FPG decreased from 9.90 to 6.89 mmol/L in insulin detemir and 10.01 to 6.78 mmol/L in insulin NPH,respectively(P0.05).HbA_1c decreased by 1.60% and 1.57%for detemir and NPH(P0.05),respectively.Compared with NPH insulin,the events of all hypoglycemia in insulin detemir group was reduced by 42%.Mean weight gain was 2.59 kg in insulin detemir and 3.10 kg in NPH insulin(P0.05).Conclusion Insulin detemir is as effective as NPH in glycemic control,but with reduced hypoglycemic events and less weight gain." @default.
- W2372847147 created "2016-06-24" @default.
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- W2372847147 date "2011-01-01" @default.
- W2372847147 modified "2023-09-24" @default.
- W2372847147 title "Efficacy and safety comparison of once-daily insulin detemir versus NPH insulin treatment as add-on therapy to previous oral antidiabetic drugs in poorly controlled type 2 diabetes" @default.
- W2372847147 hasPublicationYear "2011" @default.
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