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- W2372861003 abstract "OBJECTIVE:To evaluate the relationship of hypoxia-inducible factor-1α(HIF-1α)expression and clinicopathological features,tumor angiogenesis,and its value in the prediction of aggressive behavior of ovarian serous cystadenocarcinoma.METHODS:HIF-1α,vascular endothelial growth factor(VEGF),and basic fibroblast growth factor(bFGF)expression patterns were examined by immunohistochemistry in 52 specimens.CD34 antigen levels were also examined by immunohistochemistry to determine microvessel density(MVD)within tumors and correlations between HIF-1α expression,and clinicopathological features were examined.RESULTS:HIF-1α expression of normal and serous cystadenomas was significantly lower than that in borderline ovarian serous tumors and carcinomas(P=0.000 5,P=0.000 8).HIF-1α expression was significantly stronger in high grade or stages Ⅲ and Ⅳ or presence of ascites invasive ovarian cancer when compared with low grade or stages Ⅰ and Ⅱ or absence of ascites tumors(P=0.033,P=0.006,P=0.003).There were no significant differences in HIF-1α expression based on age(P=0.437).There was significant correlation of HIF-1α expression with expression of VEGF,bFGF and CD34 in invasive cancers(P=0.000 1,P=0.000 3,P=0.000 7).CONCLUSION:It is suggested that HIF-1α may play an important role in aggressive behavior and tumor angiogenesis in ovarian serous cystadenocarcinoma." @default.
- W2372861003 created "2016-06-24" @default.
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- W2372861003 date "2008-01-01" @default.
- W2372861003 modified "2023-09-24" @default.
- W2372861003 title "Clinicopathologic significance of hypoxia-inducible factor-1α overexpression in ovarian serous cystadenocarcinoma" @default.
- W2372861003 hasPublicationYear "2008" @default.
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