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- W2372875744 abstract "Objective To observe the effects of lysophosphatidic acid(LPA)on the action potential and contraction force in guinea pig papillary muscles.Methods Eighteen healthy adult guinea-pigs were randomly divided into LPA 0.1,1.0,10.0 μmol·L-1groups,with six guinea pigs in every group compared with themselves before administration to observe the effects of LPA on the papillary muscles.The pigs in 10.0 μmol·L-1 group were perfused with TEA 20 mmol·L-1+ LPA 10 μmol·L-1 after desorption.Results LPA 1.0,10.0 μmol·L-1 could increase contraction force in guinea pigs compared with themselves before administration from 100% to(122.6±7.9)% and(139.48±8.2)%(P0.05,P0.01).The LPA at different doses(0.1,1.0,and 10.0 μmol·L-1) could increase the action potential amplitude(APA) compared with themselves before administration from(106.79±11.80),(96.86±9.81),(100.22±7.55)mV to(113.49±12.66),(112.54±10.07),(118.91±10.62)mV(P0.05 or P0.01);the action potential durations measured at the 50% repolarization levels and the 90% repolarization levels were prolonged compared with before administation(all P0.05).TEA(20 mmol·L-1) shortened the APD50 compared with LPA 10 μmol·L-1 group(P0.05).Conclusion LPA could increase APA,prolong action potential duration and increase contraction force." @default.
- W2372875744 created "2016-06-24" @default.
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- W2372875744 date "2007-01-01" @default.
- W2372875744 modified "2023-09-23" @default.
- W2372875744 title "Effects of lysophosphatidic acid on action potential and contraction force in guinea pig papillary muscles" @default.
- W2372875744 hasPublicationYear "2007" @default.
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