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- W2372878212 abstract "Objective:To assess the therapeutic effect a nd safeness of α-dihydrorgoecryptine(α-DHEC) in the treatment of patients with Parkinson's disease in the intermediate or advanced stage that had been treated with compound dopa (L-dopa/benseragide or L-dopa/carbidopa sustained release tablets) with failing drug effects. Methods:36 patients with Parkinson's disease in the inte rmediate or advanced stage that had been treated with compound dopa with failing drug effects were given each additionally 4 ml of α-DHEC PO b.i.d, for 8 cons ecutive weeks. Webster's mark contrasting of the 10 major symptoms of the diseas e and examination of conventional laboratory indices were carried out before as well as 4 and 8 weeks after the beginning of the additional medication of α-DH EC. Results:It was shown by Webster's marking that moderate effect and slight effect could be confirmed in 10 (27.8%) and 15 (41.7%) patient s respectively. The differences between the Webster's markings of each of the 10 major symptoms of the disease before and after the additional medication with α-DHEC were significant (P0.05). 4 of the 6 patients with on-off phen omenon became dramatically ameliorated in their clinical manifestation after the additional medication. The adverse reactions were mainly gastrointestinal. No o ther serious toxic and side effects were encountered. Conclusion:It proved safe and effective to add α-DHEC to the treatment of patients with Parkinson's disease that had been treated with compound dopa with failing drug effects." @default.
- W2372878212 created "2016-06-24" @default.
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- W2372878212 date "2004-01-01" @default.
- W2372878212 modified "2023-09-25" @default.
- W2372878212 title "A Clinical Study of the Treatment of Parkinson's Disease with α-Dihydroergoc ryptine in Combination with Compound Levodopa" @default.
- W2372878212 hasPublicationYear "2004" @default.
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